Currently, diabetics rely on insulin synthesized in bacteria within complex laboratory settings.
The new method harnesses the cow’s natural milk-production capabilities as a biological factory for human proinsulin, the precursor to insulin. Surprisingly, the cow’s mammary gland even performed the conversion to active insulin.
This proof-of-concept study demonstrated the remarkable potential for transgenic cows to produce massive quantities of insulin. The researchers inserted a segment of human DNA responsible for proinsulin production into cow embryos. The resulting transgenic calf demonstrated the ability to secrete both human proinsulin and insulin in its milk.
A single liter of milk contains enough insulin that could meet the needs for a diabetic patient for several years.
Researchers envision a future where relatively small herds of these special cows could drastically lower insulin production costs and potentially meet global demand.
Unlike current bacterial production methods, this approach wouldn’t require sophisticated facilities. While further research and regulatory approvals are needed, the scientists are optimistic. This development could herald a new era of insulin availability, making this life-saving medication a reality for all diabetics, regardless of location or income.
Peoplesmind
